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Cut-off levels

What is a cut-off level??
As per AS/NZ 4308:2008  - Urine Screening
  • Cut-off levels are a measurement by which a drug test is deemed to be either negative or non-negative
  • Cut-off levels vary  for each  individual drug class  and are determined by the AS/NZ 4308:2008 & AS/NZ 4760:2006 & 4760:2019 Drug Testing Standards
  • Traces of a drug or its metabolite may be found in urine and oral fluiids, but must exceed a pre-determined amount to be deemed non-negative.
  • In New Zealand the AS/NZ 4308:2008  & AS/NZ 4760:2019 Standards dictate the cut-off levels for both immunoassay (on-site) screening and laboratory confirmations
The four tables below demonstrate the  cut-off levels for immunoassay screening  (table 1 & 3) and laboratory confirmations (table 2 & 4)  urine && oral fluids.


Table 1
The AS/NZ 4308:2008 (Urine)
Immunoassay screen cut-off levels are :
Amphetamine
type substances            300ng/ml

Benzodiazepines           200ng/ml

Cannabis
Metabolites                  50ng/ml

Cocaine
Metabolites                  300ng/ml

Opiates                       300ng/ml


Table 2
Laboratory  cut- off levels for confirmations are
as per AS/NZ 4308:2008 Standard (Urine)

COMPOUND              GC/MS (Confirmation)

Amphetamines
Methylamphetamine
Methylenedioxy-
methylamphetamine         150ng/ml
Methyldndeioxy-
amphetamine

Benzylpiperazine*
Phentermine*
Ephedrine*                     500ng/ml
Psuedoephedrine


Diazepam
Nordizepam
Oxazepam                    200ng/ml
Temazepam


A-hydroxyl-airprazolam
7-amino-clonazepam
7-amino-flunitrazepam     100ng/ml
7-amino-nitrazepam


11-nor-delta-9                 15ng/ml
Tetrahydrocannabinol-9-Carboxylic acid


Benzoylecgonine
Ecgonine methyl ester     150ng/ml


Codeine                       300ng/ml
Morphine                     300ng/ml  
6-Acetylmorphine*           10ng/ml    
*These drugs may be optionally tested within each
class and the specified cut-off levels shall apply


Table 3
The AS/NZS4760:2019 Oral Fluids
Immunoassay screen cut-off levels are :
 
Amphetamine
type substances            50ng/ml

Cannabis
Metabolites                  15ng/ml

Cocaine
Metabolites                  50ng/ml

Opiates                       50ng/ml

Oxycodne                    40ng/ml

Table 4
Laboratory  cut- off levels for confirmations are
as per AS/NZ 4706:2019 Oral Fluids Standard

COMPOUND              GC/MS (Confirmation)

Amphetamines
Methylamphetamine
Methylenedioxy-
methylamphetamine         25ng/ml
Methyldndeioxy-
amphetamine

Benzylpiperazine*
Phentermine*
Ephedrine*                     
Psuedoephedrine*


Cannabis metabloites
11-nor-delta-9                 5ng/ml
Tetrahydrocannabinol-9-Carboxylic acid

Cocaine Metabolites
Benzoylecgonine
Ecgonine methyl ester     25ng/ml

Opiates
Codeine                       25ng/ml
Morphine                     25ng/ml  
6-Acetylmorphine*       10ng/ml  


Oxycodone                  20ng/ml  

Confirming lab may also test if requested for :
Synthetic cannabinids, Cathinones, Ketamine, LSD r metabolites, Fentanyl, Methadone, Kava, Kavain, NBOMe derivatives, Tramadol & Zoipidem, Zoplicone
*These drugs may be optionally tested within each
class and the specified cut-off levels shall apply